Previously we described the use of flipped classroom strategy coupled with a team-based learning approach (FTBL). In this present study we blended Classroom Response System (CRS) with a flipped classroom approach. CRS allows students to answer questions remotely in a real-time manner and encourages them to engage with classroom activities. Our flipped CRS approach requires the students to preview the material and watch the recorded lectures before the sessions and apply their knowledge within the session either individually or as teams. Results shows students’ collaboration with one another was strongly associated with their positive feedback while using flipped CRS approach especially as teams.