Biotechnology is a high- impact science contributing to the bio-economy of a country where it is necessary to produce highly educated and skilled individuals in this discipline. Hence shaping forward-thinking learners with leadership and professional skills is important and forms a vital component of the curriculum in this discipline. E-portfolios can be powerful reflective tools in life-learning skills enhancing personal and professional development. Research also suggests that such individuals achieve higher scores on indices of success. A pilot study conducted at postgraduate level exemplifies how e-portfolios can be used as novel intervention and evaluation tools in shaping future STEM graduates.